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  • WJPPS APRIL ISSUE PUBLISHED
  • APRIL 2019 Issue has been successfully launched on 1 April 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

SYNTHESIS OF 4-[5-(4-NITROPHENYL)-4, 5-DIHYDRO-1H-PYRAZOL-3-YL]-3-(2, 4-DICHLOROPHENYL) SYDNONE AND ANTICANCER SCREENING AGAINST 60 TUMOR CELL LINES

Sachin K. Bhosale*, Shreenivas R. Deshpande, Rajendra D. Wagh and Nirmala V. Shinde

ABSTRACT

This research work seeks to synthesize of novel mesoionic compound 4-[5-(4-nitrophenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-3-(2, 4-dichlorophenyl) sydnone, Ia containing sydnone moiety to transform antitumor molecule. Compound synthesized by cyclization of 4-[1-oxo-3-(4-nitrophenyl)-2-propenyl]-3-(2,4-dichlorophenyl)sydnone, I (sydnonyl-substituted α, β-unsaturated ketone) with hydrazine hydrate. Compound Ia was characterized by spectral study and evaluated against 60 human cancer cell lines for in vitro anticancer activity and was found to have greater anticancer activity than standard vincristine sulphate against some specific cell lines. Further structural modification of the molecule might lead to development of potent antitumor molecules.

Keywords: .


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