Abstract

ANTIHISTAMINIC EFFECT OF FERONIA ELEPHANTUM BARK

Shital Chavan*, Ravi Jadhav, Manoj Damale, Shashikant Pattan

ABSTRACT

Feronia elephantum Correa (Rutaceae) bark have been used in the treatment of asthma traditionally and we therefore undertook this study to scientifically validate its benefit in asthma using various extracts and suitable animal models. Antihistaminic principles are known to be useful in the treatment of asthma; hence, in the present work, various extracts of Feronia elephantum bark were assessed using clonidineinduced catalepsy and haloperidol-induced catalepsy in Swiss albino mice. Ethanol extract (50 mg/kg, i.p.) of the plant significantly inhibited clonidine-induced catalepsy. Thus the antihistaminic activity of Feronia elephantum may be due to polar constituents.

Keywords: Feronia elephantum, catalepsy, antiasthamatic, clonidine,Antihistaminic.