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Abstract

“DEVELOPMENT & VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF ATENOLOL & LOSARTAN POTASSIUM IN BULK & TABLET DOSAGE FORM”

Avinash V. Chavan*, Dr. Ansar M. Patel, Vandana T. Narvekar, Arati R. Kapase, Shreya Gaikwad

ABSTRACT

A simple, accurate, and precise dual wavelength UV spectrophotometric method was developed for simultaneous determination of Atenolol and Losartan potassium in combined pharmaceutical dosage forms. The absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest. During the selection of two wavelengths the interfering component shows same absorbance while the component of interest shows important difference in absorbance with concentration. The literature review shows that there is no dual wavelength method was developed for this combination of drugs, hence this method was developed. The wavelengths selected for determination of atenolol were 275 nm & 253 nm, whereas, the wavelengths selected for determination of losartan potassium were 235 nm and 242 nm. Ethanol and distilled water were taken as the solvents. Correlation coefficient was found was vary from 0.974 to 0.989 for atenolol and Losartan potassium, for dual wavelength method. Accuracy of method was found between 99-101%. The precision (intra-day, interday and analyst to analyst) of method was found within limits (%CV<2). LOD was found to be 0.198 μg/ml and 1.155 μg/ml for Atenolol and 0.132 μg/ml and 0.143 μg/ml for losartan potassium for respective wavelength and LOQ was found to be 0.6 μg/ml and 3.5 μg/ml for Atenolol and 0.4 μg/ml and 0.43 μg/ml for Losartan potassium at respective wavelengths. The proposed method was successfully applied to determination of these drugs in laboratory-prepared mixtures and commercial tablets.

Keywords: losartan, atenolol, UV spectrophotometry, method validation, simultaneous estimation.


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