STEPTOZOTOCIN INDUCED DIABETIC MICE MODEL FOR ANTIHYPERGLYCAEMIC ACTIVITY OF CITRULLUS COLOCYNTHIS LINN. FLOWERS
Dr. Vijay Nigam, Dr. Manoj Kumar Mishra and Pramod Kumar Biswal
ABSTRACT
The anti hyperglycaemic effect of aqueous extract of the flowers of
Citrullus colocynthis Linn. in streptozotocin (STZ) induced diabetic
mice. The flowers extract of Citrullus colocynthis Linn. in doses 100
and 200 mg/kg b.w was administered for 21 days and blood glucose
level, serum cholesterol, liver glycogen was estimated. Treatment of
the Streptozotocin induced diabetic mice with the flower extract
resulted in significant reduction of blood glucose level (P<.0001),
serum cholesterol (P<.01) and increase in liver glycogen (P<.0001).
The results suggest that the flower extract of Citrullus colocynthis Linn
possess anti hyperglycaemic effect in Streptozotocin induced diabetic mice which justify
the traditional use of this plant as ethnomedicine in treatment of diabetes.
Keywords: Citrullus colocynthis Linn, Antihyperglycaemic, Diabetes mellitus, Streptozotocin, Oral administration.
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