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  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2019 Issue has been successfully launched on 1 January 2019

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

METHOD DEVELOPMENT AND VALIDATION FOR ASSAY OF DABIGATRAN ETEXILATE MESYLATE IN PHARMACEUTICAL DOSAGE FORM BY HPLC

*Dr. A. Sambasivarao M. S.

ABSTRACT

A new HPLC method was developed and validated for the determination of Dabigatran Etexilate Mesylate (DEM), in tablet dosage form. The chromatographic quantification and qualification was achieved on a XTerra C18 (4.6 x 150mm, 5 m) or equivalent with a mobile phase combination of Ph4.5 0.1%TFA buffer and Acetonitrile in isocratic mode in 45:55 ratio, employing flow rate of 1.0 ml/min, and the detection was carried out by using UV detector at 334 nm with total run time was 6 minutes. The retention time of DEM was found to be 2.163min. The performance of the method was validated according to the present ICH guidelines.

Keywords: RP-HPLC, Dabigatran Etexilate Mesylate (DEM).


[Full Text Article]

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