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Abstract

INVESTIGATION OF ANTIOXIDANT PROPERTY OF ETHANOLIC EXTRACT FROM RIND OF NEPHELIUM LAPPACEUM FRUIT IN NORMAL AND IMMUNESUPRESSED MICE

Priyanka Shrestha*, Mukund Handral, Suman Manandhar and Uttam Paul

ABSTRACT

One of the most conventional use of cyclophosphamide (CP) comprehends its immunosupressive effect. It has prooxidant character, and generation of oxidative stress after cyclophosphamide administration leads to decrease in the activities of antioxidant enzymes and increase in lipid peroxidation in liver, lung, spleen and serum of mice and rats. Attempts have been made in this research work, to evalutae the ethanolic extract of rind of Rambutan (Nephelium lappaceum), for its protective effect against oxidative stress and cyclophosphamide induced oxidative stress. Sheep red blood cells have been used for antigen challenge and immunization. Cyclophosphamide at a dose of 50 mg/kg body weight, for three days per oral was administered to depress the antibody production. The assessment of antioxidant activity during normal and immune suppressive state was carried by estimation of lipid peroxidation (LPO) and superoxide dismutase (SOD). The findings demonstrated 100 mg /kg and 200 mg/kg of ethanolic extract administered along with cyclophosphamide evoked prominent decrease (p<0.0001) in the level of lipid peroxidation and increase (p<0.0001) in superoxide dismutase level respectively, when correlated to the group treated with cyclophosphamide only. In addition, 200 mg/kg ethanolic extract treated group had lower lipid peroxidation and higher superoxide dismutase in comparison to normal control group. The results propose that the ethanolic extract has the ability to counteract the oxidative stress that occurs during normal antigen-antibody reaction and as well, cyclophosphamide induced immune suppression.

Keywords: Nephelium lappaceum, Cyclophosphamide, immunosuppression, sheep red blood cells, lipid peroxidation, superoxide dismutase.


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