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  • WJPPS JANUARY ISSUE PUBLISHED
  • JANUARY 2019 Issue has been successfully launched on 1 January 2019

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

FORMULATION AND EVALUATION OF EXTENDED RELEASE SOLID DISPERSION OF ANTIHISTAMINICS AGENT

Prema C. Mulkalwar*, Amit M. Gupta, Pravin K. Bhoyar, Prasad P. Kathade

ABSTRACT

Solid dispersion technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage in order to achieve increased dissolution rate, sustained release of drugs, altered solid state properties, and enhanced release of drugs from ointment and suppository bases, and improved solubility and stability. The present investigation was aim to formulate & evaluate extended release solid dispersion of antihistaminics agent. In the current study poor solubility of Rupatadine was increase by preparing Solid Dispersion by Fusion Method using PEG 6000 in the Ratio 1:4.Optimized Solid Dispersion tablet of Rupatadine, prepared using HPMC can successfully be employed as an oral controlled release drug delivery system. Optimized Formulation F2 with optimized solid dispersion ration (1:4) reduced the frequency of Dose and also increases its water solubility.

Keywords: Solid dispersion, extended release tablet.


[Full Text Article]

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