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Abstract

PREPARATION AND CHARACTERIZATION OF PHYTOSOME OF NORBIXIN

Adarsh K. Mund, Abhinasa C. Guru, Rudra Pratap Singh*, Kishore K. Pradhani, Birendra Pangi and Manoj K. Pasayat

ABSTRACT

Bixa orellana L. is reported to contain of several different classes of phyto-constituents including carotenoids, apo-carotenoids, sterols, etc. from all parts of this plant. Two types of compound of bixin (oil soluble) and norbixin, exhibit a wide range of pharmacological activities that can decrease the growth of bacteria, fungus and also proven antioxidant, anti-inflammatory acitivities. Norbixin is an alkaline water-soluble carotenoid originating from the hydrolytic removal of a methyl ester group of bixin. The key obstacle of norbixin, has low bioavailability, less soluble in water and it is rapidly eliminated from the body. The main objective of this study was to prepare the phytosome of Norbixin and evaluate it. The different molar ratio of 1:1, 1:2, 2:1 and 2:2 of phytosome of Norbixin containing norbixin and soya lecithin were prepared by the anti-solvent precipitation technique. The prepared phytosome was characterized for DSC, FT-IR, % EE, Particle size and zeta potential and SEM and evaluated by in vitro drug release study. FT-IR and DSC data showed the compatibility between norbixin and soya lecithin and also confirmed the no interaction between them. SEM study confirmed the crystalline structure, irregular shapes and smooth surface of optimized formulation. Thus, the prepared phytosome is, a carrier combining drug delivery system of soya lecithin and norbixin, is a more favorable option for topical application of norbixin.

Keywords: Norbixin, Soya lecithin, Phytosome, In vitro drug release.


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