Abstract

REVIEW ON PULSATILE DRUG DELIVERY SYSTEM AND THEIR MARKETED PRODUCT

R. J. Musale*, Pranay Jawanjal and Vishal Kulkarni

ABSTRACT

Pulsatile drug delivery system is one of the important system. It deliver the drug at the specific amount as per the pathophysiological need of the disease. Diseases where in Pulsatile drug delivery systems are promising include asthma, peptic ulcer cardiovascular diseases, arthritis attention deficit syndrome in children, and hypercholesterolemia. PDDS is best for the drugs with extensive first pass metabolism and targeted to specific site in the intestinal tract. PDDS reduces the dosing frequency so now a days it gaining more popularity and the patient compliance. The major challenge in this drug delivery system is to maintained the proper lag time by using suitable technique, and using the different polymers. For coating the suitable polymers on the tablet it is possible to controlled the lag time of the formulation. This review contains the classification, Design and Manufacturing concept, Optimization, evaluation, modeling approaches Material and Marketed product of pulsatile drug delivery system.

Keywords: Pulsatile drug delivery system, Chronomodulated, Design and Manufacturing, Evaluation, polymer, marketed product.