Abstract

EVALUATION OF CIPROFLOXACIN QUALITY IN ANTIBIOTIC RESISTANCE CASES OF ACUTE RESPIRATORY INFECTION (ARIS) IN TASIKMALAYA CITY HEALTH CENTER, INDONESIA

Danni Ramdhani*, Wiwiek Indriyati and Muhammad Aiman

ABSTRACT

Objective: ARIs is a disease of the upper and lower respiratory tract and is usually contagious and can cause various spectrums of disease. Monitoring of the quality of antibiotics is done to determine the effectiveness of the desired therapy. This study aims to determine the levels of ciprofloxacin antibiotics used in ARIs treatment. Methods: The ciprofloxacin drug sample used in this test was obtained from the health center of the city of Tasikmalaya. Testing the levels of ciprofloxacin antibiotics was carried out using HPLC systems, using validation parameters linearity, precision, accuracy, limit of detection (LOD) and limit of quantification (LOQ). Results: The test results obtained ciprofloxacin antibiotic levels 103.51%. These results indicate that the levels of ciprofloxacin antibiotics used meet the United State Pharmacopeia requirements. The test results showed that the levels of ciprofloxacin antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia grading 103.51 %, and the validation parameters that meet the requirements, correlation coefficient of 0.9941, recovery percent of 93.19%, precision 0.0105%, LOD 6.97 μg/mL and LOQ 21.11 μg/mL. Conclusions: The test results showed that the levels of ciprofloxacin antibiotics that are used to meet the requirements that exist in the United State Pharmacopeia (USP).

Keywords: Acute respiratory infections, ciprofloxacin, resistance of antibiotics, validation parameters.