Abstract

ANALGESIC ACTIVITY OF ASPHODELUS MICROCARPUS LEAVES EXTRACT

Hanae Hosni*, Khalid Taghzouti, Amina Bounihi, Yahia Cherrah and Katim Alaoui

ABSTRACT

Our study aims to investigate the existence of the analgesic activity on methanolic extract from leaves of Asphodelus microcarpus(A.m.). It's parts in the context valuation the traditional pharmacopoeia. The peripheral and central analgesic activities had evaluated by the Koster and Tail Flick tests respectively. The methanolic extract of leaves from A.m., obtained by cold maceration (yield=17.62%), the extract was subject of a study of the peripheral analgesic effect. At the dose of 50 mg/kg, this extract showed a significant inhibitory effect on the number of abdominal cramps which exceeded of aspirin, used as a reference at the dose of 200 mg/kg. About the test Tail flick, methanolic extract didn't have a significant inhibitory effect compared to morphine at the dose of 5mg/kg, on the pain caused by the heat of the light beam. Consequently, the methanolic extract of leaves from A.m. has a peripheral analgesic actvity, and its uses in traditional medicine against rheumatic pain could be justified by this activity

Keywords: Asphodelus microcarpus, analgesic activity, Koster, Tail Flick, aspirin, morphine.