Abstract

POTENTIAL THERAPEUTIC TARGETS FOR THE TREATMENT OF PARKINSON’S DISEASE

*Sharvari Lotankar and Dr. Kedar S. Prabhavalkar

ABSTRACT

In Parkinson’s disease, the presence of the neurofibrillary aggregates such as Lewy bodies are considered as a marker for neuronal degeneration and neuroinflamation. Along with this it is also characterized by the presence of the motor and non-motor symptoms as seen in Parkinsonian patients. A lot of treatment options mainly focus on the prophylactic measures or the symptomatic treatment of Parkinson’s disease such as reducing the motor symptoms of the disease. But, as such there are no treatments that are available for preventing the neurodegeneration which could ultimately help in treating the root cause of the disease. Thus, certain new targets are present which can focus on the neuroinflammation and neurodegeneration in Parkinson’s disease. These targets aid in causing alterations in those molecules which are particularly involved in causing the neuronal degeneration and neuroinflammation in Parkinson’s disease. Various targets for the treatment of the root cause of the disease are listed in this review such as adhesion G protein coupled receptor, molecular chaperones, insulin signaling, glutamate receptors, neurotransmitter CART, micro RNAs and Protein SV2C. This review encompasses the various potential therapeutic targets for Parkinson’s disease which are necessary for the treatment of Parkinson’s disease, broadly the neurodegeneration and neuroinflammation involved in Parkinson’s disease.

Keywords: Parkinson’s disease, CART, neurodegeneration, neuroinflammation, targets.