ANTHELMINTIC ACTIVITY OF PULP AND SEED EXTRACTS OF CUCUMIS MELON
Veer Bala*, Mohd Junaid, Heena Farooqui
ABSTRACT
The present study was undertaken to investigate anthelmintic effect of ethanolic extracts of Pulp & seed of Cucumis melon L. in earthworms (Pheretima posthuma). The assay was performed in vitro using adult earthworm (Pheretima posthuma) owing to its anatomical and physiological resemblance with the intestinal roundworm parasites of human beings for preliminary evaluation anthelmintic activity. Ethanolic extract of Cucumis melon L Pulp (EECMP) was used to dose of (20mg/mL) and ethanolic extract of Cucumis melon L seed (EECMS) was used to dose of (20mg/mL) and assay was performed in vitro using adult earthworm. Standard drug was Piperazine citrate (20 mg/mL) while distilled water used as control. The anthelmintic effect all the test solution and standard drug solution were prepared freshly
before starting the experiments. Observations were made for the time taken for paralysis was noted when no movement of any sort could be observed except when the worms were shaken vigorously. Time for death of worms were recorded after ascertaining that worms neither moved when shaken vigorously nor when dipped in warm water (500C). We can conclude that ethanolic extracts of pulp & seed of Cucumis melon L. produced notable anthelmintic effect which appeared to be comparable with the effect produced by the standard (Piperazine citrate). The present study provides a quantitative basis for explaining the folkloric use of Cucumis melon L. as an anthelmintic agent.
Keywords: Herbal medicine, Cucumis melon L., Ethanolic extract, Anthelmintic activity.
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