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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

SYNTHESIS AND INVITRO ANTIBACTERIAL ACTIVITY OF SCHIFF AND MANNICH BASES OF INDOLINE-2,3 DIONE DERIVATIVES

P. Jothi Rani*, Dr. M. Sundara Pandian, Dr. M. Palanivelu, A. Senthamil Selvi and A. Sathiya

ABSTRACT

In the present study, a series of Schiff and Mannich bases of Isatin derivatives were synthesized by condensation of Imesatin with different aromatic aldehydes. The Imesatin were synthesized by Isatin with p-phenylene diamine. The Mannich base was synthesized by reacting Schiff base with p-formaldehyde and secondary amine (piperazine). All the synthesized compounds have been confirmed by IR, NMR, and MASS spectroscopy analysis. These compounds were screened for antibacterial (Bacillus. subtilis, Klebsiella pneumoniae) activities by disc diffusion method using Ofloxacin (10μg/ml) as standard. Among the tested compounds SM-4 exhibited better antibacterial activity.

Keywords: Isatin, Schiff base, Mannich base, Antibacterial.

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