Abstract

SUSTAINED RELEASE MATRIX SYSTEM: AN OVERVIEW

Abdulsalam Alhalmi*, Marwan Altowairi, Omer Saeed, Nafaa Alzubaidi, Marwan Almoiliqy, Watheeq Abdulmalik

ABSTRACT

Sustained drug delivery system is one of the most useful tools that providing promising approaches to decrease the side effect of drug by preventing the fluctuation of the therapeutic concentration level of the drug in the body. The basic goals of sustained drug delivery system are to optimize the biopharmaceutical, pharmacokinetic and pharmacodynamics properties of a drug in order to maximize the utility, such a way that efficiency is maximized, reduced the side-effects and cure of the disease is achieved. Sustained release drug delivery is improve patient compliance by reduction frequency of drug administration, reduction steady-state fluctuation of drug levels, increased safety margin of low therapeutic index drug, maximum utilization of the drug, reduction in healthcare costs through improved therapy and shorter treatment period. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. Matrix tablets serves as an important tool for oral extended- release dosage. Matrix tablets may be formulated by wet granulation or direct compression methods by dispersing solid particles within a porous matrix formed of hydrophilic and hydrophobic polymers. The availability of different classes of polymers in controlling the release of drugs has become the most important aspect in the formulation of matrix tablets. The release of drug from matrix drug delivery systems by both dissolution-controlled as well as diffusion controlled mechanisms.

Keywords: Sustained release, controlled release, matrix tablet, hydrophobic polymer and hydrophilic polymer.