Abstract

ASSESSMENT OF FREE PROSTATIC SPECIFIC ANTIGEN/TOTAL PROSTATIC SPECIFIC ANTIGEN RATIO, LIPOPROTEINS, ESTRADIOL AND C – REACTIVE PROTEIN IN PROSTATIC TUMORS

Mohammed A. Mahdi*, Rihab Akasha, Gad Allah Modawe, Abd Alrauf Sharfy, Abd ElHafiz H. Khattab

ABSTRACT

Background: Prostate tumors, especially prostate cancer have severe complications such as spreading to neighboring organs. Objectives: This study was performed to compare between levels of free prostatic specific antigen (fPSA)/ total prostatic specific antigen (tPSA) ratio, lipoproteins, estradiol and C-reactive protein with prostatic cancer and benign prostatic hyperplasia patients. Materials & Methods: This study was designed as prospective case control and it was done in Soba University hospital and Khartoum Teaching hospital in Khartoum state. It was performed on 200 men (50–65 years old); 100 healthy individuals as controls and 100 patients; 50 patients with prostate cancer and 50 with benign prostate hyperplasia who were diagnosed by biopsy and histopathology. Results: There was significant increase in the mean value of total PSA in PCa patients and BPH more than controls with (P-value 0.003). Free PSA also showed significant increase in PCa patients and BPH more than controls with (P-value 0.040). The ratio of free to total PSA was decreased in PCa patients (7 %), but increased in BPH (34 %) and in control (67 %) with P-value (0.000). The mean value of serum cholesterol, triglyceride, n LDL and HDL were significantly low in PCa than BPH and control with (P-value 0.035, 0.000, 0.015 and 0.002) respectively. The mean of serum Estradiol level and CRP was increase in PCa than BPH and control with (P-value 0.025 and 0.000) respectively. Conclusion: Serum fPSA/tPSA ratio was less than 25% in patients with PCa. Total cholesterol, HDL and LDL were low in concentration in PCa patients than in those with BPH patients and control. Serum Estradiol levels increases in PCa patients more than in BPH patients and control. Serum CRP concentration was higher in PCa patients than in those with BPH and control.

Keywords: Prostate cancer, Inflammation, Hormone, Sudanese.