Abstract

DEVELOPMENT AND EVALUATION OF FLOATING TABLET CONTAINING AMLODIPINE

Abdul Yaseen*, Shivaraj D. Sadekar, Basavaraj K. Nanjwade and Priyanka K. Patil

ABSTRACT

The present investigation concerns the development of floating tablets of Amlodipine, which after oral administration are designed to prolong the gastric residence time and thereby increase drug bioavailability, and drug release rate. This would help in promoting gastrointestinal transit and speed up gastric motility, and thereby it will relieve the symptoms associated with it. The study include 9 batches of floating tablets, which were fabricated by using direct compression method; containing Amlodipine and different concentration of polymers (i.e., HPMC K4M, HPMC K15M, and HPMC K100M), along with gas generating agent sodium bicarbonate. Floating tablets were evaluated for physical characterization, uniformity of weight, thickness, diameter, hardness, friability, drug content, in vitro buoyancy studies and in vitro drug release. The best formulation was selected based upon the good result of two main parameters, i.e., in vitro buoyancy studies and in vitro drug release study with the acceptable result of other parameters. As a result formulation batch F1 was selected as best formulation, because it shows good release property of drug (97.72%) and shows best in vitro buoyancy studies and it also exhibit the acceptable result of other parameters. The drug release pattern of this optimized formulation was best fitted to zero order kinetics. The mechanism of the drug release found to be non‐ Fickian (Super case II) transport.

Keywords: Sustained Release, Amlodipine, HPMC, Sodium bicarbonate, FDDS.