Abstract

A BRIEF REVIEW ON PYRAZOLONE DERIVATIVES POSSESSING VARIOUS PHARMACOLOGICAL AND BIOLOGICAL EVALUATION

Sumathy Arunachalam*, Dr. N. L. Gowrishankar, Ankitha Krishnan, Meenu Prakash, Muhsin T., Naseena U., Poornima G.

ABSTRACT

The aim of this review is to provide an overview of diverse pharmacological activities of pyrazolone moiety. Pyrazolone derivatives are the subject of many research studies due varieties of potential biological activities such as antimicrobial antiviral, antitumor, antihistaminic, antidepressant, anti-inflammatory anticancer, Antioxidant anticonvulsant and antidiabetic activities., cytotoxic activities Pyrazolone derivatives is important moiety of numerous pharmaceuticals, agrochemicals, dyes and pigments, chelating and extracting agent. Pyrazolone can be considered as intermediate compound for synthesis of various cyclic compounds of high Biological activity the purpose of the review is to collate literature work reported by researchers on pyrazolone for their various pharmacological activity.

Keywords: Antitubercular, anti-inflammatory, analgesic, anticonvulsant, antimicrobial, anti-oxidant, anti-hypertensive, anti-viral.