Abstract

A RARE CASE REPORT ON BI-CLONAL BANDS ON SERUM PROTEIN ELECTROPHORESIS

Sushma B. J.* and Shrikant Chandrakar

ABSTRACT

The monoclonal gammopathies are a group of disorders characterized by the proliferation of a single clone of plasma cells, which produces an immunologically homogeneous protein commonly referred to as a paraprotein or monoclonal protein. Bi-clonal gammopathies are characterized by simultaneous appearance of two different monoclonal proteins. Serum protein electrophoresis (SPE) is a useful technique to separate various serum proteins based on their electrical charges and molecular weight. Commonly used supporting media are cellulose acetate and polyacrylamide. Proteins are most often stained with Ponceau S after electrophoresis on cellulose acetate and quantified by Densitometry. Normally gamma region is characterized by a polyclonal broad band. Two distinct bands in this region are quite rare. Here we present such an interesting case.

Keywords: Monoclonal gammopathy, Bi-clonal gammopathy, Serum protein electrophoresis (SPE) & Multiple myeloma.