Abstract

FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF DOMPERIDONE

Ayesha Haseena*, Asfia Kauser, Taiyaba Fatima, Zaara Majeed and Farhana Mohammed

ABSTRACT

The aim of the present study was to develop formulation of domperidone to maintain constant therapeutic levels of the drug for over 30 minutes. In the present work, mouth dissolving tablets of domperidone was prepared by direct compression and effervescent methods. All the tablets were subjected to weight variation, drug content uniformity, hardness, friability, water absorption ratio, wetting time, in vitro dispersion time, dissolution, drug excipient interaction and short-term stability studies.

Keywords: Domperidone, mannitol, magnesium stearate, aspartame.