Abstract

POTENTIAL DIURETIC ACTIVITY FROM ZINGIBERACEAE FAMILY AND ITS EFFECT ON THE LEVELS OF POTASSIUM AND SODIUM IONS IN THE URINE

Patonah Hasimun*, Agus Sulaeman, Entris Sutrisno, Hendra M. Putra

ABSTRACT

Diuretic is a class of drugs that increase urinary expenditure to overcome various diseases such as hypertension, heart failure, kidney failure. The use of loop diuretics such as furosemide is very useful, but has side effects of hypokalemia and hyponatremia. The purpose of this study was to determine the potential of zingiberaceae (20 species) as diuretics. A total of 66 male Wistar strains were grouped randomly into 22 groups (n = 3) consisting of group 1 (receiving drug carrier suspension), group 2 (receiving furosemide suspension 3.6 mg/kg) and group 3-22 received ethanol extract of zingiberaceae rhizome dose 50 mg/kg. All the groups received 5 mL of warm water orally and 10 minutes later received the test drug. The animals were placed in metabolic cages to hold urine for 5 hours. The data obtained were analyzed statistically by ANOVA method. The results showed that 19 rhizome of zingiberaceae has diuretic activity, while rhizomes of Alpinia galanga did not have diuretic activity. The diuretic activity of 10 species of zingiberaceae rhizomes, are comparable to furosemide (p>0.05). Five species of zingiberaceae did not increase the expenditure of sodium and potassium ions in urine different from furosemide (p <0.05). This study can be concluded that zingiberaceae rhizomes potentially strong as potassium-sparing diuretics.

Keywords: Diuretic, furosemide, potassium, sodium, zingiberaceae