Abstract

DESIGN AND IN-VITRO CHARACTERIZATION OF GASTRORETENTIVE FLOATING TABLETS CONTAINING GLICLAZIDE

Deepak A. Joshi*, Dr. Sidramappa M. Chickpetty, Gunesh N. Dhembre and Avinash V. Dhobale

ABSTRACT

The current work is aimed to design a novel oral gastroretentive floating tablets of Gliclazide by using combination of HPMC, carbopole 934 (CP) and guar gum (GG) for safe and effective management of non-insulin dependent (Type II) diabetes mellitus for better control of blood glucose level by enhancing its oral bioavailability and also to improve the patient compliance. The floating tablets containing 50mg of Gliclazide was prepared by direct compression technology. All the tablet formulations were evaluated for physical properties; total buoyancy and buoyancy lag time and in vitro drug release studies in pH 1.2 buffer solution. All the tablets prepared with GG / CBP alone and their combination as matrix material fails to meet the requirements of desired floating ability, sustaining and complete drug release. Among the various ratios (5:1, 4:2 and 3:3) of HPMC:GG, the ratio 3:3 meets the desired requirement (floated for 12h with a floating lag time of 30sec) and released major portion of the drug (98.64%) in 12h. The tablet formulation containing HPMC and CBP, the ratio 4:2 was found to be suitable for designing floating tablets as it has shown less floating lag time (43sec), floated for the testing period of 12h and released 97.925 of Gliclazide. The optimized tablet batch formulations showed no change in drug content or in vitro release pattern after storage at 40o C / 75% RH for 30 days. The FTIR studies ruled out incompatibility between the drug (Gliclazide) and non drug components used in the tablets.

Keywords: Gliclazide, carbopole, guar gum, FDDS, gastric residence time, diabetes mellitus.