Abstract

SUPERDISINTEGRANTS: IMPORTANCE AND ROLE IN FORMULATION OF ORODISPERSIBLE TABLETS

Dr. R. Santosh Kumar* and Sahithi Mudili

ABSTRACT

Orodispersible tablets dissolve or disintegrate immediately on the patients’ tongue or buccal mucosa. This drug delivery system is suitable for drugs undergoing high first pass metabolism. It improves bioavailability, reduces dosing frequency, and thereby minimizes the side effects and also makes the dosage form more cost-effective. This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. In recent years, several newer agents have been developed known as superdisintegrants. Different types of superdisintegrants have been using such as semi synthetic, synthetic, natural and co-processed blends employed to develop effectual orodispersible tablets and to overcome the limitations of conventional tablet dosage forms. This review article describes the various kinds of superdisintegrants along with their role in tablet disintegration and drug release.

Keywords: Orodispersible tablets, Superdisintegrants and Bioavailability.