Abstract

DESIGEN, FORMULATION AND EVALUATION OF EFFERVESCENT TABLET OF ALENDRONATE SODIUM WITH VITAMIN D3

Gayke A. U.*, Aglawe S. B., Sancheti V. P. and Mohan R. S.

ABSTRACT

Alendronate sodium is a bisphosphonates which has antiresorptive effect which is implicated in the prophylaxis and treatment of osteoporosis. The objective of the present investigation is to formulate effervescent tablet of Alendronate sodium with Vitamin D3 against osteoporosis thereby improving patient compliance. Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. Effervescent tablets were formulated using Tartaric acid and sodium bicarbonate as effervescent composition by wet granulation. Formulation was evaluated for weight variation, thickness, hardness, solution time, pH of solution & content uniformity. The Effervescent tablet of Sodium Alendronate and Vitamin D3 is a new pharmaceutical formulation to be taken orally and offering a considerable advantage: avoidance of gastro-intestinal disorders, to the limits of the possible. As compared to the pure drug and marketed tablet, this formulation displayed significantly effective in the oral osteoporosis treatment in post-menopausal women.

Keywords: Effervescent tablet, Alendronate sodium, Vitamin D3, Osteoporosis.