Abstract

A REVIEW: MELTSONOCRYSTALLIZATION TECHNIQUE USED FOR IMPROVEMENT OF SOLUBILITY

Shelake Sardar*, Shewale Shital, Patil Shitalkumar, Patil Sachinkumar, Mujawar Nigar and Gaikwad Pranali

ABSTRACT

Melt sonocrystallization method have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. It is a novel particle engineering technique to enhance dissolution of hydrophobic drugs that is having less water solubility and to study its effect on crystal properties of drug. It forms agglomerates with number of shallow circular pits on the surface leads to increase solubility by improving its shape from crystalline to amorphous that is obtain circular shape. Melt sonocrystallization process was developed for poorly soluble drugs in which these poorly soluble drugs melt was poured in deionized water maintained at 600C and simultaneously subjected to ultrasonic energy. The agglomerates obtained after solidification of dispersed droplets were separated by filtration and dried at room temperature. Hence this review gives valuable information about on melt-sonocrystallization shows that there is increase in solubility of poorly water soluble drugs.

Keywords: BCS Class, solubility, sonocrystallization, melt sonocrystallization, bioavailability, advantages.