Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF ZIDOVUDINE

Kamlesh A. Kadiya*, Dr. Anil S.Solanki, Dr. Vishnu M.Patel Dr. Anand K. Patel

ABSTRACT

The aim of the present study was to formulate and evaluate the fast dissolving tablets of zidovudine using superdisintegrants. Zidovudine an antiretroviral drug belonging to nucleosides reverse transcriptase inhibitor has achieved immense popularity in the treatment of HIV and AIDS related conditions. The advantage of ease of swallowing and no need of water has led to better acceptability amongst the dysphasic patient. FDTS of zidovudine were prepared by direct compression technique using natural and synthetic superdisintegrants and evaluated for pre-compression parameters like bulk density, tapped density, carr’s index, hausner ratio and post compression parameters like hardness, disintegration time, thickness, friability, wetting time, drug content, weight variation, in-vitro release, stability studies. FTIR
studies indicated no interaction between drug and excipients. All the parameters showed good results. The result was found to be that among the nine formulation the Z6 formulation was found to be the best as it shows disintegration time 14.53 seconds and maximum drug release of 99.42% at 4 minutes. It was subjected to accelerated stability studies for one month. The formulation was found to be stable.

Keywords: Zidovudine, Fast Dissolving Tablet, Sodium Starch Glycolate, Isapgula mucilage, direct compression.