Abstract

INTERACTION OF METILENDIOXIMETANFETAMINA VS. NEUROTRANSMITTERS AND THE RELATIONSHIP BY THE QUANTUM METHOD

Jesús Francisco Mondragón-Jiménez, Bernardo Ojeda-Lara, Adrián Alvarez-Aguilar, Carlos Arturo Brito-Pérez, Francisco José Rosales-Hernández and Manuel González-Pérez*

ABSTRACT

Background: Methylenedioxymethamphetamine (MDMA) is a psychostimulant derived from amphetamines, commonly known as "ecstasy. MDMA causes the release of serotonin, dopamine (DA) and norepinephrine (NA) by blocking presynaptic reabsorption transporters. MDMA causes prolonged toxic effects to the serotonergic nerve terminals and, more recently. A neurotransmitter (NT) is a chemical released selectively from a nerve ending by the action of an action potential. The AD by B-adrenergic stimulus increases the contractile force of the myocardium and enhances the frequency of myocardial contraction. AD is involved in various signaling processes in the central nervous system (CNS). Method: It used HyperChem molecular simulator for Windows Serial # 12-800-1501800080. Semi-empirical parametric method 3 (SE-PM3) to extracting the molecules. When comparing the interaction of two substances by this theory, there is a range of the Electron transfer coefficient (ETC) of a substance (A) and an ETC of substance (B). Result: when comparing MDMA with the NTS we find that it has a strong affinity with the following NTS: AD, DA, ASP, and GLU due to its low ETC. Conclusion: We conclude that the MDMA has a high electronic transfer to the NTSs: AD principally, DA, Asp, Glu.

Keywords: MDMA, adrenaline, dopamine, glutamic acid and aspartic acid, SE-PM3 and quantum methods.