Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF METOCLOPRAMIDE HCL

Kadam V. S.*, Bharkad V. B., Shete G. A., Jameel A., Shendarkar G. R. and Jadhav S. V.

ABSTRACT

Oral films dissolve rapidly along with drug in mouth and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism. The aim of present investigation was to formulate and evaluate the Fast dissolving oral films (FDOF) of Metoclopramide HCl (anti-emetic drug). Metoclopramide HCl film formulations were prepared by solvent casting technique using HPMC E5, E15, K4M, K15 as film forming polymer and PEG-400 as plasticizer. The prepared films were evaluated for their appearance, thickness, folding endurance, weight uniformity, % drug content, surface pH, tack test, disintegration time and in-vitro dissolution studies.

Keywords: Metoclopramide HCl; fast dissolving oral films; Solvent casting method; In vitro dissolution.