Abstract

CURCUMIN LOADED CASEIN MICROCARRIER SYSTEMS TO MODIFY WATER DISPERSIBILITY AND DELIVERY CHARACTERISTICS

Roopa G.,*, Jayanthi C., Srinidhi, Roopa Karki, Hanumanthachar Joshi and Goli Divakar

ABSTRACT

The aim of the present study is to prepare curcumin loaded casein microcarrier Systems to modify water dispersibility and delivery characteristics. Casein based curcumin microparticles were prepared by simple coacervation phase separation using pH change method. Morphology and surface characteristics of the formulations were assessed by scanning electron microscopy. The Mean particle size of casein curcumin loaded microparticles, were found to be in the range of 32 ± 0.22 to 63 ± 0.45 μ. The yield of the formulations varied from 85 ± 0.79 to 95 ± 0.92%. The percent of drug loading was in the range of 23 ± 0.21 % to 45 ± 0.45 % and the percentage encapsulation efficiency was in the range of 84% to 94%. The FT-IR spectra ascertained the compatibility of curcumin with the polymer. Microparticulate formulations containing 1:1 ratio of curcumin and casein exhibited comparatively faster and complete release (CCMP1, 4 and 7) than 1:2 and 1:3. Results obtained revealed that cross linking time of 2-6 h with glutaraldehyde 25% v/v did not influence the dissolution profiles of microparticulate formulations. SEM images exhibited irregular shaped discrete particles. CCMP3 was identified as the optimum formulation owing to sustenance of drug release.

Keywords: Curcumin, casein, microparticles, glutaraldehyde, pH coacervation phase separation, controlled release.