Abstract

FORMULATION AND EVALUATION OF METOPROLOL TARTARATE ORAL DISINTEGRATING TABLETS

G. Sandhyarani*, J. Srikanth and M. Sarangapani

ABSTRACT

Orodispersible dosage forms are used for accurate dosing, enhanced bioavailability, rapid action, patient compliance, easy of administration, enhanced palatability. The aim of the experiment is to formulate metaprolol tartrate oral disintegrating tablets using different superdisintigrants like (Sodium starch glycolate (SSG), Croscarmellose sodium (CCS), Crospovidone (CP), Low-subsitituated hydroxypropyl cellulose (L-HPC). 12 formulations of tablets were prepared using direct compression method and the formulated tablets were subjected to different physicochemical evaluation tests like hardness, weight variation, disintegration, thickness, drug content uniformity, water absorption ration, wetting time and In vitro dissolution. From the results of drug release and disintegration time formulation F9 containing, crosspovidine 5% as superdisintegrant was selected as the optimized formula for the formulation of disintegration tablets of metaprolol tartrate.

Keywords: Sodium starch glycolate (SSG), Croscarmellose sodium (CCS), Crospovidone (CP), Low-subsitituated hydroxypropyl cellulose (L-HPC).