PREPARATION AND CHARACTERIZATION OF FLOATING MICROSPHERES OF CIPROFLOXACIN HYDROCHLORIDE
Nethaji Ramalingam*, Mohamed Jassim A., Sunusha Praveen, Manikandan Palanivelu, N. Subramaniam Surendiran and Babu Ganesan
ABSTRACT
Ciprofloxacin hydrochloride (Hcl) is a fluoroquinolone antibiotic and
effective against a gram positive and negative bacterial infections. It’s
highly lipophilic and rapidly well absorbed after oral administration.
The present study Ciprofloxacin Hcl floating microspheres were
formulated with different concentration and blend of polymers like
Ethyl cellulose, HPMC K4 M and HPMC K15M by non-aqueous
solvent evaporation technique with an aim to controlled release and
improve bioavailability. Depending upon the drug to polymer ratio, the
percentage yield is found between 78.25% to 89.27% in all
formulations. The entrapment efficiency of prepared floating
microspheres was in the range of 72.67% to 89.27%. Microspheres
showed a good specificity, spherical and uniform in shape with smooth
surface and the mean particle size of microspheres significantly increase with increasing
polymer concentration and it was range between 180.12±0.31 to 222.43±0.35 μm. Percentage
buoyancy of floating microspheres was in the range of 69.87% to 85.36%. In-vitro drug
release studies were performed in simulated gastric fluid which revealed that CP-III
formulation was 98.53% drug release and CP-VII found 98.08% drug releases at the end of
dissolution studies. Stability studies of selected floating microspheres showed good results. It
could be also concluding that the all the formulations were shown satisfactory results and
suitable for potential therapeutic uses.
Keywords: Ciprofloxacin Hcl, Floating Microspheres, In-vitro drug release, Stability studies.
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