FORMULATION AND EVALUATION OF COMPRESSION COATED TABLETS OF DEFLAZACORT FOR COLON TARGETING
Dhanalakshmi. K*, Ramesh Kumar. K, Elango. K, Vivek. V
ABSTRACT
The present study was designed to minimize the drug release in upper gastro intestinal tract and target to colon by using the principles of compression coat. Compressed coated tablets (CCT) were prepared in two steps; initially immediate release core tablets were prepared using Croscarmellose sodium, Sodium starch glycolate, Crospovidone as superdisintegrants by wet granulation method. The prepared core tablets were evaluated for uniformity of weight, hardness, friability, disintegration, drug content and in-vitro dissolution studies. F2 formulation of core tablets disintegrate at 17 s and releases 97.06 % of drug at 5 min selected for compression coating. In the second step, compression coating was done by using pH dependent polymers
Eudragit S-100 (ED S-100) and Eudragit L-100 (ED L-100) in different ratios 1:1, 1:0, 0:1, 4:1, 3:2, 2:3, 2:1, 1:2. The prepared compression coated tablets were evaluated for uniformity of weight, hardness, friability and Drug content. In-vitro drug release studies were carried out in different pH (1.2, 5.5 & 6.8). All the formulations were best fitted with zero order kinetics and mechanism of drug release was non-Fickian (super case-II). FT-IR studies revealed that there was no drug-excipient interaction. In this study compression coated tablets that was resistant to gastric and intestinal pH conditions but can be easily dissolved in colonic pH. The results indicate that C-7 (2:1) formulation can be promising vehicle for colon-targeted delivery of Deflazacort.
Keywords: Deflazacort, Colon targeted drug delivery, pH-dependent delivery system, Inflammatory bowel disease, Superdisintegrant.
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