Abstract

FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF DEFERASIROX

Kiritkumar N. Patel*, Dr. Ravi Patel, Anil G. Raval, Ankur Upadhyay and Krunal Sharma

ABSTRACT

The present study was aimed to formulate and evaluate immediate release tablet of Deferasirox as oral iron chelating agent used for the treatment of chronic iron overload. Also Deferasirox is BCS class II drug, so it has poor solubility. Here Deferasirox IR tablet was formulate with improved solubility. Solubility was improved by using micronized Deferasirox and Drug Resin Complex by solid dispersion technique. Deferasirox immediate release tablet was prepared by direct compression method with Drug Resin Complex (DRC). In this direct compression method six DT agent was examined with Sodium lauryl sulphate. Out of six different DT agent croscarmellose sodium and Polyplasdone XL-10 was selected for further optimization based on the DT and dissolution results. The result of analysis indicate that optimum amount of DT agent should be used. The formulated tablet showed compliance for various physicochemical parameters viz. Hardness, Friability, Thickness, Drug content, disintegration test and in-vitro dissolution test. Deferasirox immediate release tablet formulation further optimized by using 22 full factorial design. In 22 full factorial designs D-27 optimized batch was selected with DT agent Croscarmellose sodium and Polyplasdone XL-10 because it has satisfactory results of disintegration time and in-vitro dissolution profile.

Keywords: Deferasirox IR Tablet, Croscarmellose Sodium, Polyplasdone XL-10, SLS and Kyron T114.