Abstract

FABRICATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF ORAL HYPOGLYCEMIC DRUG

Talat Farheen*, Azmat Shaikh and Dr. Sadhana Shahi

ABSTRACT

Pioglitazone hydrochloride is an oral hypoglycemic agent used for treatment of diabetes type-2. The aim of this study is to develop a mucoadhesive microparticulate system of Pioglitazone hydrochloride, which have the ability to reside in the gastrointestinal tract for an extended period and can be utilized for controlled release of Pioglitazone hydrochloride in oral administrations. Mucoadhesive microspheres were prepared by emulsification ionic gelation technique using polymers, sodium alginate and xanthan gum. Microspheres prepared were found to be discrete, nearly spherical, free flowing, showed good entrapment efficiency and mucoadhesion. The release of drug from the spheres was slow. The formulation PF8 showed good mucoadhesion, drug entrapment and extended drug release of 92.26% upto 12 hours.

Keywords: Emulsification ionic gelation, Xanthan gum, Sodium alginate, Pioglitazone hydrochloride.