Abstract

CAPSAICIN AND ITS USE IN DIFFERENT PAINFULL PATHOLOGIES

Dr. Gilberto Quiñonez Palacio*, M.C. Lizbeth Mariela Cerón Ramírez, Dra. María de los Angeles Lea

ABSTRACT

Diabetic neuropathy is the primary and most important factor in the development of plantar ulcers, 15% of diabetics suffer from this and up to 60% of diabetics suffer from diabetic neuropathy; even some authors raised that diabetes may present with comitantamente symptoms of neuropathy, these data is more than eloquent on the importance of the study. In industrialized countries, diabetes is the most common cause of neuropathy. The vast majority of patients with this physiopathology has a distal symmetrical form which progresses to a pattern of longitudinal-fiber damage with predominant sensory, autonomic manifestations. The pathogenic base is a distalaxonopathy. It has beenfound in some diseases the use of oral capsaicin at 0.25% is effective to reduce the pain as in oral burning syndrome. Capasicin is a member of the vanilloid family, selectively binds to vanillic receptors subtype 1 (VR1), these are receiving channel-Ionic type that are related to the family of receptor potential vanilloid 1 (TPR1) and are located in the membranes of sensory neurons for pain and heat. Capsaicin also releases the firing of neuropeptides P of sensory nerve fibers type-C. Capsaicin receptors play an important role in the transmission of heat, pain and inflammation. ―Perspective: this is a literature review of published studies on the use of capsaicin as an analgesic for treating diabetic neuropathy. To understand this disease is extremely important to assess the high frequency in our environment and thereby to establish standards of education and treatment with the objective of reducing the high frequency.

Keywords: neuropathy, neuropeptide P, capsaicin.