Abstract

FORMULATION AND EVALUATION OF THE GLIEMPRIDE NANOPARTICLE BY COMPLEX COACERVATION METHOD

Prevesh Kumar*, Dr. Devender Pathak and Pawan Singh

ABSTRACT

Nanoparticle of Glimepiride for oral delivery were prepared by ion gelation method using polyelectrolyte charge interaction glimepiride is an effective antidiabetic agent, however it suffers from short biological half-life. Therefore, it was selected as a model drug, the prepared nanoparticles were evaluated for Physic-chemical studies like drug polymer interaction through FTIR Analysis, surface morphology by scanning electron microscopy (SEM), percent drug entrapment, production yield, in-vitro drug release characteristics. The result of FTIR Studies showed that there was no drug polymer interaction found. The SEM studies confirm that with increase of polymer concentration the nanoparticle became smooth with surface roughness and In-vitro release showed that the drug release followed diffusion for formulation F5, F6, and F7 and for the formulation F8, F9 and F10 followed non-fickian mechanism, moreover all the formulation exhibited high percentage yield as well as high percent drug entrapment. This method proves beneficial in designing controlled release formulation of glimepiride chitosan-Gelatin-B Complex Ion-gelation methods, using polyelectrolyte charge interaction.

Keywords: Nanoparticle, Glimepiride, Chitosan, Gelatin-B, Ion-Gelation Method, Polyelectrolyte charge interaction.