Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE ANTIFUNGAL EMULGEL OF VORICONAZOLE

Aney J. Samuel and Mujahid Ahmad*

ABSTRACT

Voriconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. Commercially Voriconazole topical gel preparation are not available in the market, thus this formulation is made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The sustained release emulgel was formulated by changing the polymer ratio. FT-IR study confirmed the purity of drug and revealed no interaction between the drug and excipients. Emulgel formulations were characterized for drug content, pH determination, viscosity measurement, in vitro diffusion, antifungal activity and skin irritation. The objective of this project was to develop Emulgel for sustain release of voriconazole. In present work we prepare emulsion and then incorporated in carbopol gel. The result of studied revealed that the optimized batch shows 94.27% release in 24 hours and stable for around there. Hence it can be concluded that emulsion based system is more effective and safe system for sustained delivery of antifungal agent(s). Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.

Keywords: Emulsion, Gel, Emulgel, Voriconazole, Topical drug delivery.