Abstract

LIPID PROFILE IN PATIENTS WITH GASTRITIS

Fatima Thegel Moutar, Abdulghani Mohamed Alsamarai*, Farooq Ibrahem Mohammad

ABSTRACT

Background: H. pylori infection is the most predominant worldwide and may be associated with metabolic and nutritional changes. Aim: to investigate the association between H. pylori infection and changes in serum lipid profile in an Iraqi population. Patients and methods: Seventy two subjects with H. pylori infection and 64 individuals with H. pylori negative test as control. Total cholesterol, triglyceride and HDL determined using direct enzymatic assay using kits. Results: The mean serum of cholesterol, triglyceride, and LDL were significantly higher and HDL was significantly lower in H. pylori positive group as compared to H. pylori negative group. OR and AUC confirmed a significant positive association between H. pylori infection and BMI, age and gender. However, OR not showed an association between H. pylori infection and lipid profile mean serum levels, while AUC indicated a significant association between H. pylori infection and mean serum levels of cholesterol, triglyceride and LDL. Conclusion: H. pylori was associated with increase in serum cholesterol, triglyceride and LDL and decrease in serum HDL. These changes may act as risk factor for development of cardiovascular disease in subjects with H. pylori infection.

Keywords: H. pylori, gastritis, d yspepsia, stomach carcinoma, cholesterol, triglyceride, LDL, HDL, lipid profile.