Abstract

THERAPEUTIC EFFECT OF FLAVONOIDS AS ANTI-INFLAMMATORY AGENTS

Kalpesh Sonar* and Deepa Purohit

ABSTRACT

Flavonoids are polyphenolic aggravates that happen pervasively in plants having an assortment of natural impacts both in vitro and in vivo. They have been found to have antimicrobial, antiviral, anti-ulcerogenic, cytotoxic, anti-neoplastic, mutagenic, antioxidant, antihepatotoxic, antihypertensive, hypolipidemic, antiplatelet and anti-inflammatory activities. Flavonoids likewise have biochemical impacts, which restrain various proteins, for example, aldose reductase, xanthine oxidase, phosphodiesterase, Ca(+2)-ATPase, lipoxygenase, cyclooxygenase. They additionally have an administrative part of various hormones like estrogens, androgens and thyroid hormone. They have been found to have mitigating action in both proliferative and exudative periods of inflammation. A few components of activity have been proposed to clarify mitigating activity of flavonoids. The point of the present survey is to give an outline of the instrument of activity of potential anti-inflammatory flavonoids.

Keywords: flavonoids, inflammation, anti-inflammatory activity, cytokines, nitric oxide, arachidonic acid metabolites.