Abstract

ROLE OF OXIDATIVE STRESS IN BREAST CANCER

Dhara Bhatt*, Khushboo Jethva, Sonal Patel and Maitreyi Zaveri

ABSTRACT

Breast cancer is the most common form of cancer worldwide. Reactive oxygen species (ROS) are produced by both enzymatic and non-enzymatic systems within eukaryotic cells. They play an important role in cellular physiology and pathophysiology. ROS overproduction is detrimental to cells, and it is considered as one of the key-factors for the development of several diseases, such as neurodegenerative diseases, cardiovascular disorders, and cancer. Cancer initiation and progression has been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation. The role of ROS on breast cancer etiology and progression is being progressively elucidated. In this review, we address the causes and Consequences of oxidative stress in breast cancer and also the emerging possibilities of breast cancer therapies targeting ROS homeostasis.

Keywords: Breast cancer, reactive oxygen species, breast cancer therapy.