SYNTHESIS, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF SOME NEW 2-PYRAZOLINES
Dr. Ch. Prasad*, Dr. Y. Srinivasa Rao and A. Kanakaraju
ABSTRACT
A new series of chalcones (1a-h) were synthesized by condensation of 3-acetyl-2,5-dimethyl thiphene with various substituted aromatic aldehydes by claisen – Schmidt condensation method. The resulted chalcones react with phenyl hydrazine HCl in presence of pyridine to give 1,3,5 – Trisubstituted 2-Pyrazolines CHP (1-8). All these pyrazolines were characterized by means of their IR, H1NMR and elemental analyses. Newly Synthesized compounds were evaluated for anti-inflammatory, antibacterial and antifungal activities.
Keywords: 2-Pyrazolines, Synthesis, Anti-inflammatory and antimicrobial activity.
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