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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHY METHOD FOR THE ANALYSIS OF ALFUZOSINE HCL IN PHARMACEUTICAL DOSAGE FORMS

*Vilas Arsul, Manoj Shere and Supriya Wagh

ABSTRACT

The objective of the current study was to develop a simple accurate, precise and rapid RP-HPLC method development and validation for determination of Alfuzosine HCl in tablet dosage form. Chromatographic separation was achieved on C18 Column with mobile phase Acetonitrile :( 0.05%) OPA (40:60) v/v with flow rate 0.7ml/min and UV detection was carried out on 245nm. Retention time of Alfuzosine HCL was found to be 4.9167 & Linearity of proposed method was found to be in the range of 10-50 μg/ml (r2=0.997). Method was statistically validated for its linearity, accuracy and precision. Both interday and intraday variation was found to be showing less %RSD (Relative Standard Deviation) value indicating high grade of precision of method.

Keywords: RP-HPLC Method, Alfuzosine HCl, Validation.

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