Abstract

IONTOPHORESIS DRUG DELIVERY SYSTEM

Lohe R. G., Jadkar S. S.*, Modekar S. D. and Bhusare K. M.

ABSTRACT

Iontophoresis is the process of increasing the penetration of drugs into the skin by application of an electric current. This technique facilitates movement of ion across a membrane under the influence of an externally applied potential difference is one of the most promising physical penetrations enhancing method. The goal of delivery system is to get optimal therapeutic management. In this article, we discuss the mechanism, principles, factors influencing iontophoresis and its application for various dermatological condition. Recently the Iontophoretic technique has been widely used. The reason behind using this technique is the capability of this method to increase the systemic delivery of high molecular weight compounds. Also improved systemic bioavailability, ensuring from bypassing the first pass metabolism. This review briefly describes the history of iontophoresis and discussion of factors which affect the Iontophoretic drug delivery.

Keywords: Iontophoresis, Topical drug delivery, Penetration into skin, Transdermal drug delivery Penetration Enhancers, etc.