Abstract

RECENT ADVANCES IN NANOGELS DRUG DELIVERY SYSTEMS

Bishnu Adhikari*, Cherukuri Sowmya, Chappidi Suryaprakash Reddy, Chinthaginjala Haranath, Hari Prasad Bhatta, Raghavendra Naidu Inturi

ABSTRACT

Nanogel drug delivery has remained as one of the most challenging task for pharmaceutical scientists at this 21st century. From the last 3 decades ocular drug delivery research accelerated advanced towards developing a novel, safe, patient compliant formulation and drug delivery devices/ techniques which may suppress these barriers and maintain drug level in tissues. Controlled and sustained delivery of ophthalmic drugs have a major focus area in the field of pharmaceutical drug delivery with emergence of new, more potent drugs and biological response modifiers that may also have very short biological half-life. The major objective of controlled and sustained delivery is to provide and maintain adequate concentration of drugs at the site of action. Anterior segment drug delivery advances are treatment by the conventional topical solutions with permeation and viscosity enhancers. On the other hand, for the posterior ocular drug delivery, research has been immensely focused towards development of drug releasing devices & treatment for chronic vitreo-retinal diseases. Polymers with nanogel proposed are reported to be devoid of any irritant effect on cornea, iris, conjunctiva and thus appear to be a suitable inert carrier for ophthalmic drug delivery. Nanogels based materials have high drug loading capacity, biocompatibility and biodegradability which are the key points to design & drug delivery system effectively. Recently different types of nanogel along with the synthetic procedure & mechanism of drug release from nanogel carrier are mainly focused. An intensive study of clinical trial in future will confirm nanogel as a suitable carrier for drug.

Keywords: Nanogel, polymers, controlled and sustained release, bioavailability, novel drug delivery systems.