Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF DENDRICREAM FOR WOUND HEALING ACTIVITY OF ARTEMISIA INDICA.

Shalu Rani*, Amanjot, Harjaskaran, Narinder Singh, Surya Prakash Gautam, Sukhbir Kaur

ABSTRACT

The present study was intended to examine comparative wound healing potential of herbal extract and herbal dendricream with marketed standard formulations of Povidone-iodine using excision wound models in normal rats. The crude extract was administered topically in different doses for evaluating the wound healing potential in excision wound model for fourteen days. WHC [Formulation No. 6 (F-6)] showed significantly better wound healing activity than standard cream. F-6 also demonstrated complete epithelization and good collagen deposition as compared to standard cream. The experimental data of wound size area that, expressed healing in the cream treated group of animal was significant as compared to control group of animal. It was observed that the formulated dendricreams showed better wound healing activity.

Keywords: wound healing, artimisia indica, dendricream, invitro study,invivo study, stability studies.