Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF PONGAMIA PINNATA LINN., SEED EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN WISTAR RATS

S. Elamathi*, N. Jayshree and R. Priyadharshini

ABSTRACT

The present study was carried out to evaluate the hepatoprotecive activity of an ethanolic extract of Pongamia pinnata L., seed (EEPPS) on carbon tetrachloride (CCl4) induced hepatotoxicity in wistar rats. Administration of EEPPS at different doses and standard drug Silymarin to rats showed a significant hepatoprotective activity against CCl4 induced hepatotoxicity. Elevated serum marker enzymes of AST, ALT, ALP and Total bilirubin were significantly reduced to near normal level in EEPPS treated rats. The extract was also increases the level of Total protein and albumin. LPO level was decreased significantly in EEPPS 200mg/kg, 400mg/kg dose treatment groups. In case of antioxidant enzymes SOD levels was increased significantly in EEPPS treated animals 200, 400mg/kg doses.

Keywords: Pongamia pinnata L., Hepatoprotective activity, Carbon tetrachloride, Silymarin, Hepatic marker enzymes.