Abstract

SYNTHESIS AND EVALUATION OF SOME NEW THIAZOLE / OXAZOLE DERIVATIVES FOR THEIR BIOLOGICAL ACTIVITIES

Bhupender Singh Rawat* and Shrawan Kumar Shukla

ABSTRACT

The Benzimidazoles, 1,2,4 triazoles, thiazolidinones, oxadiazoles, pyridine and pyrimidine nucleus has diverse pharmacological activities such as antibacterial, anthelmintic, antifungal etc. The thiazole nucleus is also known to possess various biological activities viz. antidepressant, hypertrophy, cardiac, bactericidal, anaesthetic and antifungal activity. The aim of this work is to study the effect of three methoxy group on the course of the reaction with substituted thiazole/oxazole nucleus and on the antibacterial & antifungal activity of the synthesized products. The synthesized compounds were investigated against Staphylococcus aureus, B.subtilis, P. Aeruginosa, and E.coli for antibacterial study and against C. Albicans, Aspergillus Niger for antifungal activity.

Keywords: Thiazole, Oxazole, trimethoxybenzaldehyde, Antifungal, Antibacterial activity.