Abstract

DEVELOPMENT OF COLON TARGETING DRUG DELIVERY SYSTEM USING PLANT POLYSACCHARIDE

Bhanu Priya*, Shubham Verma and Nitin Sharma

ABSTRACT

An attempt has been made to formulate colon targeted tablet dosage form of metronidazole as model drug using natural polysaccharide extracted from Abelmoschus moschatus (Mushkadana, family- Malvaceae). In preliminary study, extracted polysaccharide was characterized in terms of physicochemical properties. Swelling study at different pH confirmed, utility of plant polysaccharide as a colon targeting carrier. Core tablets were prepared by changing the concentration of polysaccharide (10 to 30 mg) and using wet and dry granulation method. Optimized core tablets were coated by compression coating with 350 mg polysaccharide (Abelmoschus moschatus). The amount of metronidazole released from tablets at different time intervals was estimated by UV-Spectroscopy method. In-vitro dissolution studies revealed that natural polysaccharide based colon targeted tablet was successfully following the release pattern specific to colon delivery. It was observed that release of drug was become rapid by decreasing the concentration of extracted polysaccharide. The result of the studies shows that compression coated formulation of metronidazole tablets with 350 mg of Abelmoschus moschatus polysaccharide as coating material is most likely to provide targeting of drug for local action in the colon owing to its minimal release of the drug in the first 5 hr.

Keywords: Colon, Abelmoschus moschatus, Metronidazole, Natural Polymer, Anti Amoebic.