Abstract

FORMULATION AND IN-VITRO EVALUATION OF LORNOXICAM LOADED SOLID SELF MICRO-EMULSIFYING DRUG DELIVERY SYSTEM: A BIOENHANCEMENT APPROACH

Dipti G. Phadtare* Pankaj P. Pawar and Ravindra B. Saudagar

ABSTRACT

To enhance the solubility and Bioavailability of poorly soluble drug Lornoxicam, Self micro-emulsifyning drug delivery system (S-SMEDDS) was developed and evaluated. Solubility studies, ternary phase diagram, emulsification ability and central composite design (CCD were used as primary tools to select the components of the of system and optimized the composition of liquid SMEDDS of lornoxicam. Liquid SMEDDS containing lornoxicam was formulated using Labrafil M 1944 CS as oil, Labrasol as surfactant and Transcutol-P as co-surfactant respectively.The liquid SMEDDS containing lornoxicam (with globule size 213.5nm and poly dispersibility index 0.324) optimized formulation (F9B) containing Labrafil M 1844 CS (18%), Labrasol (14%) and Transcutol-P(28) was converted to solid SMEDDS by using adsorbent carrier as Syloid 244FP by adsorption on carrier technique. The DSC and IR spectrarevels that presence of lornixicam in molecular state in solid SMEDDS. The in vitro dissolution study indicates improved dissolution characteristic with higher percent drug release for solid SMEDDS (101.68%) compared to marketed preparation (72,88%) with in 20 min. In vivo bioavailability assessment in rat was performed for anti-inflammatory activity using solid SMEDDS it showed a quick effect as compared to marketed formulation. In conclusion, SMEDDS for potential system for improved oral delivery.

Keywords: Lornoxicam, micro-emulsifyning The DSC and IR spectrarevels that presence of lornixicam in molecular state in solid SMEDDS.