Abstract

MOLECULAR DOCKING STUDY OF COMPOUNDS DERIVED FROM POLYHERBAL EXTRACT ON G-PROTEIN COUPLED PROKINECTICIN RECEPTOR AND C-REACTIVE PROTEIN.

Ragavan Balliah* and Monisha Sudhakar

ABSTRACT

PKR1 and C- reactive proteins have emerged as a critical mediator of cardiovascular Homeostasis and cardioprotection. Identification of PKR1 and CRP inhibitors that contribute to Myocardial repair will support for treatment of heart diseases such as Myocardial infarctions. through in silico docking studies, we characterized the PKR1 and CRP antagonists, demonstrating their cardioprotective activity against myocardial infarction (MI). Based on high throughput docking protocol, five compounds was chosen from phytochemicals and Computationally screened for putative PKR1 and CRP inhibitory activity, using a homology model. Among the five compounds selected, 5,5’ Biphthalide was found to possess highest in silico inhibitory activity against both C- reactive proteins and G- protein coupled receptor.

Keywords: C- reactive protein, Myocardial infarction, Plant compounds, PKR-1